Implants for cartilage and bone repair
CartiHeal has developed an innovative technology for repairing hyaline cartilage (cartilage found in the weight bearing joints such as the knee, ankle, and big toe) and underlying bone. Cartilage injury affects over 35 million people in the U.S. alone, and represents a major unmet need, as hyaline cartilage has very limited ability for self-repair, and cannot on its own heal after an injury. Therefore, cartilage injuries often cause severe pain and dysfunction. Also, research has shown that injuries to cartilage in the joints, if left untreated, lead to progressive joint changes and early onset of osteoarthritis.
The most common treatments for cartilage injuries (e.g. microfracture and osteochondral grafting) fall short, as they result in generation of fibrocartilage, or "hyaline-like" cartilage, which does not have the biomechanical properties of original hyaline cartilage, and cannot withstand weight-bearing forces. Patients who do not respond to conservative treatments and pain relievers and are not yet candidates for knee replacement lack a solution altogether.
CartiHeal's first product, the Agili-C implant, is designed to repair cartilage and bone in bodily joints, by way of a minimally-invasive, single-step procedure, that takes just several minutes. The implant has a unique structure, comprising of calcium carbonate and hyaluronic acid. The implant biodegrades in the implantation site, and promotes the repair of the cartilage and subchondral bone. CartiHeal's headquarters are located in Kfar Saba, Israel.